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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yihan Liu

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Oct 2026

Engineering of an Fe2+/α-Ketoglutarate-Dependent Dioxygenase Enables Stereoselective and Efficient Sulfoxide Synthesis

Alliin (S-allyl-l-cysteine sulfoxide) is a valuable bioactive sulfur compound and an allicin precursor. However, its biocatalytic synthesis is limited by poor stereocontrol of an Fe2+/α-ketoglutarate-dependent dioxygenase (l-isoleucine dioxygenase, IDO) that converts S-allyl-l-cysteine (SAC) into alliin. Herein, we a...

Zhao-Lin Song, De-Quan Liu, Fang-Yue Bi et al. · 0 citations
Sep 2026

Channel-Guided Engineering of Tryptophan Synthase β-Subunit for High-Level Biosynthesis of the Garlic Bioactive Compound S-Allyl- l -Cysteine

S-Allyl-l-cysteine (SAC) is a bioactive organosulfur compound from aged garlic that has attracted considerable interest for its health-promoting properties. Here, we developed a channel-guided engineering strategy to enhance SAC biosynthesis using the β-subunit of tryptophan synthase (TrpB). Genome mining guided by c...

Zhao-Lin Song, De-Quan Liu, Zhao Zhang et al. · 0 citations
Open access Sep 2026

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

ABSTRACT Enzyme turnover number (kcat) is a central kinetic parameter for biocatalysis, but experimental determination is low‐throughput and existing computational methods inadequately model enzyme–reaction interplay. Here, we introduced MCKcat, a deep learning framework that integrates multi‐scale convolutional featur...

Feng-Ya Ge, Xiang-Yang Ma, Ji-Yan Li et al. · 0 citations
Sep 2026

Biochemical Characterization of a Novel β-N-Acetylhexosaminidase for Efficient Production of N-Acetyl Chitotriose.

Results indicated that AuHex92-pNP-GlcNAc exhibited a stable, compact conformation, which enhanced its substrate affinity and transglycosylation activity, which establishes a foundation for producing (GlcNAc)3 in the food, chemical, and pharmaceutical industries.

Tian-Yu Wang, Xue-Jing Liu, Qing-Xuan Zhao et al. · 0 citations
Jul 2026

Structure-informed engineering of a laccase with enhanced catalytic activity and thermostability for facilitating lignocellulosic biomass saccharification.

Lignocellulose is an abundant renewable feedstock for biofuels and value-added bioproducts, yet its efficient bioconversion is hindered by the recalcitrant lignin barrier. While laccases show great potential for lignin modification and delignification, their limited thermostability restricts their application in high-t...

Lei Zhao, Dianqing Liu, Yi-Min Cai et al. · 0 citations

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