Myeloperoxidase/ASGPR Dual-Targeting Self-Amplifying Nanoplatform for Synergistic Anti-Metastatic Therapy of Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) remains highly lethal due to a complex tumor microenvironment (TME) that limits therapeutic efficacy. Herein, a dual-targeted nanotherapeutic platform (SC@GRT-COF-366) based on a covalent organic framework (COF-366) is reported for synergistic HCC treatment. This multifunctional system in...