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Author

Yiming Shao

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Aug 2026

Combining network toxicology, single-cell RNA sequencing, and in vitro/in vivo experimental models reveals MMP9 as the key mediator of 27-hydroxycholesterol-driven ovarian cancer.

27-Hydroxycholesterol (27-HC), as a major cholesterol metabolite, has been shown to be associated with tumor biology, but its role in ovarian cancer remains unclear. This study integrates network toxicology, multi-cohort transcriptomic validation, and single-cell RNA sequencing to systematically investigate the potenti...

Xin-Tong Li, Yiming Shao · 0 citations

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