Author

Yiming Zhang

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Open access Sep 2026

VeloHARMO: a deep learning framework for mRNA coding sequence generation and design via translation velocity harmonization

Abstract Heterologous gene expression often results in suboptimal protein yield or activity, potentially influenced by differences in translation dynamics between native and host organisms. Conventional mRNA design approaches based on codon usage frequency can improve expression efficiency. However, codon usage frequen...

Bian Bian, Ji-Chen Zhang, Yi-Ming Zhang et al. · Briefings in Bioinformatics · 0 citations

Preprint Aug 2026

MolBioKG: Grounding Out-of-Graph Molecules in Biomedical Knowledge Graphs via Multi-Resolution Structural Anchoring

This work introduces MolBioKG, a two-layer system that grounds unseen molecules in biomedical evidence via multi-resolution structural anchoring and outperforms strong baselines across in-graph link recovery, complex multi-hop reasoning, and out-of-graph generalization.

Yiming Zhang, Hikaru Shindo, Shuan Chen et al. · 0 citations