Author

Yin-Bo Liu

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Open access Sep 2026

Gene-Chronos: parameter-efficient developmental time inference using a pretrained single-cell foundation model

Abstract Large-scale single-cell and spatial transcriptomic atlases enable the study of developmental processes at high resolution. However, most datasets capture only static snapshots of cells, making it difficult to infer continuous biological time from transcriptomic profiles. Existing temporal inference methods oft...

Yin-Bo Liu, Han-Di Gao, Tian Tian · Briefings in Bioinformatics · 0 citations

Open access Sep 2026

Decoupling topological and molecular features for interpretable biomolecular interaction prediction

Abstract Predicting biomolecular interactions is fundamental to understanding cellular mechanisms and advancing drug discovery. However, biomolecular interactions exhibit immense diversity across multiple dimensions. Most existing computational methods are designed to handle one specific task or data modality, which li...

Qi Wu, Yin-Bo Liu, Feng-Jie Yang et al. · Briefings in Bioinformatics · 0 citations