Integrated bulk and single-cell transcriptomic analyses with experimental validation identify PLOD1 as a diagnostic biomarker and TGF-β1-responsive profibrotic mediator in dupuytren’s disease
Dupuytren’s disease (DD) is a progressive fibroproliferative disease characterized by palmar fascia fibrosis, extracellular matrix deposition, and finger contractures. Reliable diagnostic biomarkers and regulatory mechanisms have not yet been fully defined. Firstly, integrate the public transcriptome datas...