Open access
Sep 2026
Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance.
An FAP/TREM2-targeting bispecific antibody is developed to disrupt this spatial nexus and restore therapeutic sensitivity in MDR patient-derived xenograft models with favorable safety.
K. Shen, Lu Wang, Zi-Xu Gao et al.
· Cell Reports Medicine · 0 citations