Lab-in-a-Tube System Integrating Hierarchically Wrinkled Electrodes and DNAzyme-Functionalized Beads for Diagnosis of Clostridioides difficile Infection.
The diagnosis of bacterial infections remains slow because many existing methods rely on enrichment steps such as nucleic acid amplification or growth culture. RNA-cleaving DNAzymes offer a promising route to accelerate bacterial diagnosis because they can be selected and programmed to specifically recognize disease-ca...