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Sep 2026

Zhuche Pill alleviates DSS-induced colonic epithelial injury in mice: involvement of IL-17/NF-κB and Wnt/β-catenin signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE Zhuche Pill (ZCP), a traditional Chinese medicine formula first documented in Qianjin Yaofang during the Tang Dynasty, has been used for centuries to treat dysentery-associated gastrointestinal disorders, including abdominal pain, diarrhea, hematochezia, and tenesmus. Despite the long-sta...

Tao-Tao Zhang, Bei-Yang Cong, Zhi-Cong Yang et al. · 0 citations
Open access Sep 2026

Dioscin activates myeloid AMPK to restore Lgr5⁺ stem cell homeostasis and promote mucosal repair in ulcerative colitis.

Dioscin ameliorates experimental colitis and dysplasia by activating myeloid AMPK signaling, inhibiting IL-1β-driven macrophage-ISC dysregulation, and restoring epithelial regeneration, highlighting macrophage metabolic reprogramming as a therapeutic strategy and identifying myeloid AMPK as a potential target for UC in...

Nian-Ka Huang, Shu-Ru Lu, Qiu-Wei Zhong et al. · 0 citations

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