Author

Ying-Jia Li

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Open access Aug 2026

Engineered bacteria reverses tumor cuproptosis resistance via cancer-associated fibroblast reprogramming for enhanced immunotherapy

Cuproptosis, a novel modality of mitochondrial copper-induced cell death, holds great therapeutic potential against cancer. However, its efficacy is limited by cancer-associated fibroblasts (CAFs), which confer the cuproptosis resistance in tumor by upregulating the copper exporter ATP7A. In this study, we developed an...

Yu-Hao Chen, Xiao-Rui Geng, Ning Su et al. · Materials Today Bio · 0 citations

Review Sep 2026

[Research progress and application status of nanobody-drug conjugate(NDC) in cancer treatment].

This review summarizes the discovery and structural characteristics of nanobodies, the construction strategies for NDCs, their applications in tumor therapy, and the synergistic potential of nanobodies with other treatment modalities to provide insights for future research and development of NDCs in oncology.

Ge-Lin Xian, Ying-Jia Li, Meng-Yuan Hu et al. · Xi bao yu fen zi mian yi xue... · 0 citations