Author

Ying-Jun Li

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Sep 2026

Bioluminescence-based high-throughput screening and identification of direct-acting dengue virus NS5 methyltransferase inhibitors.

Dengue virus (DENV) is a mosquito-borne orthoflavivirus that infects millions of people annually across tropical and subtropical regions, posing a severe and growing threat to global public health. Currently there are no antiviral drugs available for DENV infection. The methyltransferase domain of non-structural protei...

Chen-Chen Li, Jian-Fang Zhang, Yue-Gao Hu et al. · International Journal of Bio... · 0 citations

Open access Sep 2026

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

This work establishes that NS1 coopts PARP1 phase separation via the HD rheostat to prolong transcriptional pausing, introducing ‘phase transition correction’ as an antiviral paradigm.

Shu-Feng Ma, Chang-Yuan Kang, Xi-Xian Liu et al. · Advancement of science · 0 citations

Open access Sep 2026

New Class of Uridine- and Adenosine-Based Morpholino Nucleosides as Potential Anti-SARS-CoV-2 Agents: Synthesis, Antiviral Evaluation, Molecular Modeling, and In Silico ADMET Properties

A novel library of 38 fused bicyclic morpholino-uridine and -adenosine derivatives was constructed through an innovative, single-step strategy based on a reductive aminocyclization reaction between readily prepared nucleoside secodialdehydes and bifunctional amines, emphasizing the potential of this fused bicyclic syst...

Rasha Ghanem Kattoub, M. Bege, Erika Mező et al. · ACS Bio & Med Chem Au · 0 citations