Chemical proteomic identification of STUB1 as a direct target of benzophenone-3 reveals disrupted NRF2 signaling in chondrocytes.
Osteoarthritis (OA) is a common age-related degenerative joint disease, and emerging evidence implicates environmental chemical exposures as potential contributors. Benzophenone-3 (BP-3), a widely used ultraviolet filter frequently detected in human biospecimens, has been associated with increased OA risk, yet its dire...