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Author

Yingping Zhuang

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Sep 2026

Programming 2,3-butanediol biosynthesis in Saccharomyces cerevisiae with AI-optimized dual-optogenetic switches.

Microbial cell factories promise sustainable biomanufacturing, yet balancing cellular growth and product synthesis remains a fundamental productivity bottleneck. While traditional static metabolic engineering fails to precisely orchestrate metabolic flux across temporal and spatial dimensions, optogenetic approaches of...

Sai-Nan Yang, Ren-Mei Liu, De-Chong Ou et al. · 0 citations
Open access Jul 2026

Machine Learning Gap-Fills Missing Transporter Kinetics in Biosystems Across Scales

The first compound-protein interaction machine learning model of transporter Vmax and Km, MMTKPred is developed, which captures the effects of point mutations and substrate changes on transporters and effectively models metabolite transport spanning from molecular to multi- species scales.

Sizhe Qiu, Zhangyu Guo, Weiming Tu et al. · 0 citations

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