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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ying-Qi He

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Open access Aug 2026

Discovery of novel dual-target CDK12/PARP1 inhibitors for the treatment of triple-negative breast cancer.

The dual-target CDK12/PARP1 inhibitor 20b developed herein represents a novel lead molecule for TNBC drug development and exhibited markedly superior antiproliferative effects compared with single-target inhibitors and effectively reduced pSer2-CTD and PAR levels in TNBC cells.

Zhi-Jian Zhong, Miao Sun, Zhi-Wen Luo et al. · 0 citations

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