Open access
Sep 2026
Levofloxacin enhances 5-fluorouracil efficacy in colorectal cancer by activating the DDR-TP53-mitochondrial apoptosis axis
Summary 5-Fluorouracil (5-FU)-based regimens are a cornerstone of colorectal cancer (CRC) chemotherapy. Levofloxacin (LVF), a widely used fluoroquinolone antibiotic, has been reported to exhibit anticancer properties. We investigated LVF’s ability to enhance CRC chemosensitivity to 5-FU in cell lines, subcutaneous xeno...
Chen-Meng Huang, Chen-Chen Sun, Han Wang et al.
· iScience · 0 citations