Author

Ying-Xue Dong

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Review Open access Sep 2026

Immune checkpoint inhibitor-associated arrhythmias: clinical challenges, artificial intelligence-enhanced monitoring, and management strategies

Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic landscape for a broad spectrum of malignancies, substantially prolonging patient survival. However, the widespread clinical adoption of ICIs is challenged by a diverse array of cardiovascular immune-related adverse events (CV-irAEs). Among these, a...

Yi-Fu Xia, Hao-Yu Dong, Xiang-Zhu Meng et al. · Frontiers in Cardiovascular... · 0 citations

Open access Sep 2026

The CMPK2–mtDNA axis mediates doxorubicin cardiotoxicity: mechanistic links to STAT1 transcription and FAD-mediated inhibition

Doxorubicin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity. The precise mechanisms bridging mitochondrial dysfunction to cardiac inflammatory responses remain poorly defined. We utilized cardiomyocyte-specific CMPK2 knockout and overexpression mou...

Zhen-Yu Feng, Li Lin, Yi-Jin Yang et al. · Cellular & Molecular Bio... · 0 citations