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Oct 2026

AAV-mediated Siglecf elimination on TAMs reverses TMZ therapy-induced T cell dysfunction in glioblastoma.

Glioblastoma (GBM) is the most aggressive primary tumor of the brain, characterized by extensive intratumor heterogeneity, and exhibits inevitable recurrence despite conventional therapy. This study investigates the immunosuppressive mechanisms underlying GBM recurrence following temozolomide (TMZ) therapy, with a spec...

Zhen-Kun Yang, Jie Li, Da-Xing Xu et al. · 0 citations
Open access Oct 2026

Connective tissue disease-associated interstitial lung disease: immune profiling and correlation of immune cells with pulmonary function in SSc-ILD

Abstract Background Connective tissue diseases (CTDs) frequently involve the lungs, with CTD-associated interstitial lung disease (CTD-ILD) representing a leading cause of morbidity and mortality, yet the immunopathological mechanisms remain incompletely defined. This study characterized immune profiles in CTD-ILD and...

Zhen-Kun Yang, Hui-Xing Li, C. Qin et al. · 0 citations

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