Open access
Aug 2026
Combined hydrogen and oxygen therapy attenuates vascular cognitive impairment in rats via gut microbiota-derived SCFA-GPR41/PI3K/Akt/Nrf2 signaling
It is found that HHOS significantly improved spatial memory and reduced anxiety-like behaviors in BCCAO rats, and outperformed monotherapies by coupling microbiota-SCFA restoration with GPR41/PI3K/Akt/Nrf2-mediated antioxidant defense, supporting a novel dual-gas strategy for VCI.
Xin-Lei Fu, Meng-Zhuo Ma, Yujing Zhang et al.
· Scientific Reports · 0 citations