Author

Ying-ying Zhang

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Open access Sep 2026

The primary somatosensory cortex mediates trigeminal neuralgia induced depressive-like behaviors through an indirect pathway targeting the lateral habenula

Trigeminal neuralgia frequently co-occurs with depression, aggravating clinical outcomes. The primary somatosensory cortex (S1), a key pain-processing region, exhibits hyperactivity linked to chronic pain. Moreover, S1 integrates nociceptive inputs to modulate pain-related affective disturbances. However, it rema...

Yuan-Zeng Wang, Tian-En Si, Ying-Ying Zhang et al. · The Journal of Headache and... · 1 citation

Review Open access Sep 2026

Deep brain stimulation mechanisms in comorbid pain and emotional dysregulation from animal models

Summary Deep brain stimulation (DBS) is a potent neuromodulatory intervention for chronic pain and comorbid affective disorders. This review synthesizes preclinical evidence detailing the neural circuits and molecular cascades engaged by DBS in models of pain and emotional dysregulation. We delineate how DBS-targeting...

Tian-En Si, Hao Han, Ying-Ying Zhang et al. · iScience · 0 citations

Aug 2026

Glutamatergic neurons in the nucleus accumbens represent a distinct functional population that gates pain.

BACKGROUND The nucleus accumbens (NAc) integrates affective and sensory information crucial for pain processing. While canonically viewed as a predominantly GABAergic structure, the potential existence and function of non-canonical excitatory populations remain poorly understood. We hypothesized that a distinct subpopu...

Tian-En Si, Zhi-Xiao Li, Ying-Ying Zhang et al. · Regional anesthesia and pain... · 0 citations