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Author

Ying-Yu Chen

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Open access Aug 2026

Carboxypeptidase A6 contributes to bovine enterovirus F production through apoptosis-associated PI3K/AKT/FOXO1 signaling

A genome-wide CRISPR/Cas9 loss-of-function screen in Madin–Darby bovine kidney cells identifies CPA6 as a previously unrecognized host factor for BEV-F infection, support a model in which CPA6 is functionally associated with PI3K/AKT/FOXO1 signaling related to apoptosis, and suggest that carboxypeptidase-associated pat...

Yuanchen Geng, Hao Yang, Qimeng Wu et al. · 0 citations
Open access Jul 2026

SH3PXD2B is the critical host factor promoting the entry of mycobacteria

A genome-wide CRISPR-KO library is constructed and results indicate that SH3PXD2B is a critical host factor manipulated by M. bovis to promote macrophage phagocytosis and inhibit migration, thereby facilitating bacterial invasion and reveal a new pathogenic strategy.

Donghui Liu, Ting Zhang, Yu-jie Sheng et al. · 0 citations
Jul 2026

The AAA+ chaperone ClpB contributes to stress tolerance and pathogenesis in Mycoplasma bovis.

It is demonstrated that ClpB serves as a multifunctional virulence determinant in M. bovis, orchestrating stress adaptation, host-pathogen interactions, and pathogenic potential through modulation of both protein quality control systems and virulence-associated pathways.

Hui Zhang, Doukun Lu, Gang Zhao et al. · 0 citations

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