A genome-wide CRISPR/Cas9 loss-of-function screen in Madin–Darby bovine kidney cells identifies CPA6 as a previously unrecognized host factor for BEV-F infection, support a model in which CPA6 is functionally associated with PI3K/AKT/FOXO1 signaling related to apoptosis, and suggest that carboxypeptidase-associated pat...
A genome-wide CRISPR-KO library is constructed and results indicate that SH3PXD2B is a critical host factor manipulated by M. bovis to promote macrophage phagocytosis and inhibit migration, thereby facilitating bacterial invasion and reveal a new pathogenic strategy.
Donghui Liu, Ting Zhang, Yu-jie Sheng et al.· Applied and Environmental Mi...· 0 citations
It is demonstrated that ClpB serves as a multifunctional virulence determinant in M. bovis, orchestrating stress adaptation, host-pathogen interactions, and pathogenic potential through modulation of both protein quality control systems and virulence-associated pathways.
Hui Zhang, Doukun Lu, Gang Zhao et al.· International Journal of Bio...· 0 citations
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