Author

Ying Yuan

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Preprint Sep 2026

A staggered seamless dose-optimization design for co-developing monotherapy and combination therapy

Contemporary oncology drug development increasingly requires efficient dose-optimization strategies that evaluate monotherapy (Mono) and combination therapy (Combo) while balancing activity, efficacy, and tolerability. We propose a staggered seamless phase I/II design for settings in which a novel agent is evaluated al...

M. Kojima, Kentaro Takeda, Ying Yuan · 0 citations

Preprint Oct 2026

Adaptively Combining Randomized and External Control Data Using a Mixture Prior in the Presence of Heterogeneity

When resources are limited in a randomized trial, a common strategy is to augment data from the control arm with external controls. We propose a hybrid group sequential Bayesian design that uses this approach to compare time-to-event distributions. The design allows between-treatment effects to differ between patient s...

Xin-Yi He, Peter F. Thall, Ying Yuan et al. · 0 citations