Aug 2026
The DreAM-plus integrative RNA switch enhances transient AAV expression and reduces side effects of gene editing.
The uncontrolled long-term adeno-associated virus (AAV) expression prohibits therapeutic strategies that require more precise and dynamic regulation. For example, long-lasting expression of gene editors by AAV could augment off-target effects and immunogenicity. Drug-inducible RNA switches are desirable tools to achiev...
Yue-Yang Zhang, Yuhan Yang, Zhanzhao Liu et al.
· Molecular Therapy · 0 citations