Author

Yizhi Jane Tao

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Open access Aug 2026

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

This work identifies VCP as a druggable node for host-directed immunomodulation and highlights SKI-II as a prototype small molecule that boosts host tolerance to infection, thereby validating the C. elegans-based screening platform for discovering immunomodulators active in mammalian systems.

Li-Yang Zhang, Kai Ye, Charilaos Dellis et al. · mBio · 0 citations

Open access Aug 2026

Resolving Orsay Virus δ Protein Architecture Using Molecular Rulers in Single-Molecule Force Spectroscopy

This label-free method provides the first mechanical evidence of the δ protein’s multi-domain architecture, establishing a robust, multi-dimensional framework for decoding the mechanics of complex biomolecular assemblies in their native state.

Cynthia S. Deem, Sithara S. Wijeratne, Tsung-Cheng Lin et al. · bioRxiv · 0 citations