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Purpose To evaluate the feasibility of local excision (LE) as an organ-preserving approach in patients with locally advanced rectal cancer showing a good response to neoadjuvant chemoradiotherapy (CRT). Materials and Methods This prospective, multicenter, single-arm phase II study enrolled patients with cT2-3N0-2M0 r...
In metastatic disease, EOCRC shares a conserved canonical genomic backbone with AOCRC, indicating that it is not a genomically distinct entity, which suggests that CRC arising at younger age may reflect distinct age-associated biological vulnerabilities.
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