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Review Sep 2026

Damage-associated molecular patterns in skeletal muscle: a double-edged sword - from sterile inflammation initiation to precision targeted therapeutic strategies.

Skeletal muscle repair after injury depends on a tightly coordinated cascade of inflammatory and regenerative responses. Damage-associated molecular patterns (DAMPs) link tissue damage to innate immune activation, but their effects are highly context dependent. This review summarizes the major cellular sources of DAMPs...

Zi-Hui Gao, Xia Li, Ya-Nan Ji et al. · 0 citations
Review Open access Aug 2026

Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design

Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...

Yutong Wei, Jie Wang, Ya-Nan Ji et al. · 0 citations

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