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Review Open access Sep 2026

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

ABSTRACT Targeted protein degradation (TPD) redirects endogenous protein‐disposal pathways to selectively eliminate therapeutically relevant proteins. Over the past two decades, this field has progressed from proteolysis‐targeting chimeras (PROTACs) to an expanding repertoire of proteasomal and lysosomal degradation st...

Kong-Jun Liu, Xue-Yin Yuan, Yan Zhou et al. · 0 citations

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