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Open access Sep 2026

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding. Meth...

Haihui Jiang, Lin-Xi Cao, Xiao-Dong Chen et al. · 0 citations
Oct 2026

Use of structure-function coupling to assess compensatory motor cortex flexibility and predict postoperative motor outcomes in patients with motor area gliomas.

OBJECTIVE The objective of this study was to investigate the mechanisms of motor compensation in glioma patients by quantifying both the structural decoupling index (SDI) value and the integrity of transcallosal white matter tracts. The authors aimed to evaluate their individual and combined utility in predicting long-...

Xi-Jie Wang, Tao Yu, Xiao-Kang Zhang et al. · 0 citations

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