Open access
Aug 2026
CPS1 promotes colorectal cancer progression by inducing EMT and activating TGF-β/Smad signaling pathway
Summary Colorectal cancer (CRC) is a highly lethal digestive malignancy, particularly in metastatic cases. Carbamoyl-phosphate synthase 1 (CPS1), a key mitochondrial enzyme involved in the urea cycle, has been implicated in multiple cancers. However, its role in CRC remains poorly understood. This study demonstrated th...
Ning Qu, Jinglian Chen, Yanlu Chen et al.
· iScience · 0 citations