Protein mutation effect generation asks a model to describe the functional consequence of a point mutation in natural language. Existing protein-to-text systems typically encode mutation information into undifferentiated representations, overlooking the organization of mutation-induced evidence across structural and bi...
Liuzhenghao Lv, Yu-Yang Liu, Yu-Yang Gao et al.· 0 citations
TCRspec, an interpretable multimodal framework combining sequence embeddings, gene-usage features, and complex-level structural representations, providing a structure-informed framework for TCR specificity prediction, is developed.
Jia Zou, Zong-Ying Lin, Yi-Min Wang et al.· Journal of Chemical Informat...· 0 citations
UniWorld-View is introduced, a unified framework for controllable large-baseline novel view synthesis from monocular inputs that integrates explicit 3D guidance with generative diffusion modeling to enable precise camera control and geometrically consistent view generation.
Hai-Yang Zhou, Wang-Bo Yu, Chaoran Feng et al.· 2 citations
Determining molecular structures from spectroscopic data remains fundamentally challenging because the inverse problem is intrinsically underdetermined: individual spectra are sparse, low-dimensional, and encode only partial structural evidence relative to the vast space of possible molecules. We address this challenge...
Chengchun Liu, Zhiyuan Yan, Li Yuan et al.· 0 citations
By combining protein language model embeddings with topology-adaptive geometric reasoning, DiConSite offers a reusable framework for residue-level protein interaction analysis and achieves consistently strong and often best-performing results, while improving robustness to structural uncertainty and cross-modal variati...
Shou-Zhi Chen, Zhen-Chao Tang, Lin-Lin You et al.· IEEE Transactions on Pattern...· 1 citation
HME is presented, a framework that combines multiple views of molecules to improve molecular understanding and design and enables bidirectional navigation of the chemical-linguistic space, achieving consistent improvements across molecular comprehension and design tasks over strong baselines.
Liuzhenghao Lv, Hao Li, Yu Wang et al.· Nature Communications· 0 citations
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