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Yong-Hu Sun

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Open access Aug 2026

Shared and Distinct T‑Cell Receptor Characteristics of CD4+ and CD8+ Drug-Specific T‑Cells In Vitro Generated from Healthy Donors and Hypersensitive Patients

The initiation of T-cell-mediated drug hypersensitivity reaction requires the formation of a human leukocyte antigen (HLA)-peptide-drug-T-cell receptor (TCR) complex. While specific interactions between HLA molecules and drug antigens are well-defined, the characteristics of drug binding to the TCR are unclear. Herein,...

Kanoot Jaruthamsophon, Paul J. Thomson, J. Pratoomwun et al. · 0 citations

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