Author

Yong Huang

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Review Open access Sep 2026

Neuropeptide Y signaling in osteoarthritis pain: neuroimmune mechanisms, joint remodeling, and translational opportunities

Osteoarthritis is a leading cause of chronic musculoskeletal pain, but pain severity is not fully explained by cartilage loss or radiographic damage. Neuropeptide Y is a multifunctional neuropeptide with receptor- and compartment-dependent effects on nociceptive signaling, sympathetic activity, immune regulation, and s...

Heng Qiu, Li Wang, Dan-Ni Luo et al. · Frontiers in Pain Research · 0 citations

Review Open access Sep 2026

Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies

Skeletal degeneration is a major cause of pain, disability, fragility fracture, and loss of independence in aging populations. Although osteoporosis, osteoarthritis, and intervertebral disc degeneration are usually managed as anatomically separate disorders, they share a common regenerative failure: endogenous stem and...

Xin-Ling Wang, Yong Huang, Tian-Min Zhu et al. · Regenerative Therapy · 0 citations