Sep 2026
A Non-canonical role of phloretin in renal protection: Targeting WNT2B downregulation to prime PINK1/ PARKIN-dependent mitophagy and attenuate renal fibrosis.
Renal fibrosis, the common pathological endpoint of diverse kidney injuries, drives the progression to end-stage kidney disease. Its rising prevalence, mirroring the global chronic kidney disease burden, starkly contrasts with the unmet need for safe and effective therapies. Fibrogenesis is centrally driven by transfor...
Xue Wu, Yong-Hui Dong, Jia Li et al.
· Phytomedicine · 0 citations