Trichoxanes A (1) and B (2), two novel sorbicillinoids featuring a unique cage-like 2,7-dioxa-pentacyclo[7.4.0.03,8.05,13.06,10]tridecane scaffold, were isolated from Trichoderma reesei via a molecular networking strategy. Their structures were elucidated by spectroscopic analyses, CASE, DP4+ NMR calculations, and EC...
Rui Jiang, Xin-Yu Zheng, Xing-Piao Jin et al.· Organic Letters· 0 citations
Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represe...
Han-Xiao Zeng, Yaxing Wang, Chen-Meng Huang et al.· Chinese Journal of Natural M...· 0 citations
(±)-Hypericandrone A and (+)-1 displayed potent antitubercular activity by selectively inhibiting the acetyltransferase domain of Mycobacterium tuberculosis GlmU through a dual mechanism, acting competitively against acetyl-CoA and noncompetitively against glucosamine-1-phosphate.
