Spatial multi-omics technologies provide unprecedented opportunities to characterize tissue organization by measuring complementary molecular layers within their native spatial context. However, simultaneous profiling of multiple molecular modalities remains technically challenging, limiting the widespread application...
Zhengxuan Liu, Peimeng Zhen, Bingtao Wang et al.· bioRxiv· 0 citations
Spatial omic technologies have revolutionized tissue analysis by enabling multimodal molecular coprofiling within their native tissue context. Integrating multislice spatial multiomic data offers unprecedented opportunities to reconstruct three-dimensional (3D) tissue landscapes from multimodal molecular perspectives....
Peimeng Zhen, Han Shu, Bingtao Wang et al.· Genome Research· 0 citations
Case studies further validated predicted circRNA-drug associations, including cisplatin, enzalutamide, and sorafenib, against published experimental findings, demonstrating HMCDSP's capacity to reveal clinically relevant biomarkers and inform personalized therapeutic strategies.
Yong-Tian Wang, Wen-Kai Shen, Jiahao Li et al.· Interdisciplinary Sciences C...· 0 citations
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