Open access
Aug 2026
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
ABSTRACT Liquid–liquid phase separation (LLPS) is essential for proper DNA damage signaling. The sequential formation of PAR‐ and 53BP1‐based condensates must be tightly controlled in space and time, however the molecular regulators of this process remain insufficiently defined. Here, we show that RSF1 contains a subst...
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang et al.
· Advancement of science · 0 citations