Open access
Jul 2026
OTUB1 inhibits autophagy-dependent ferroptosis in hepatocellular carcinoma by stabilizing p62 via non-canonical deubiquitination
Findings reveal that OTUB1 drives HCC progression by stabilizing p62 to block autophagy-dependent ferroptosis, a novel therapeutic strategy to overcome drug resistance and improve outcomes in advanced HCC.
Peng-Cheng Zhao, Yong-Xin Wang, N. Saeidi et al.
· Cell Death Discovery · 0 citations