Open access
Sep 2026
A Cross-Region Meta-Analysis and Machine Learning Identifies a 37-Gene Signature Associated with Alzheimer’s Disease
Background/Objectives: Alzheimer’s disease (AD) shows marked transcriptomic heterogeneity across brain regions, limiting reproducibility. We aimed to identify robust cross-region gene signatures using meta-analysis. Methods: Differential expression (limma-voom) was performed on five bulk RNA-seq datasets (n = 230; 154...
Kashvi C. Shah, Ethan Littlestone, M. R. Ahmmad et al.
· Biomedicines · 0 citations