Dicoumarol suppresses intrahepatic cholangiocarcinoma growth via modulation of the PI3K/Akt signaling pathway.
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy after hepatocellular carcinoma (HCC), characterized by high invasiveness and poor clinical prognosis. Dicoumarol (Dic) is a naturally occurring coumarin compound that was previously used clinically as an anticoagulant. In recent ye...