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Oct 2026

Dicoumarol suppresses intrahepatic cholangiocarcinoma growth via modulation of the PI3K/Akt signaling pathway.

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy after hepatocellular carcinoma (HCC), characterized by high invasiveness and poor clinical prognosis. Dicoumarol (Dic) is a naturally occurring coumarin compound that was previously used clinically as an anticoagulant. In recent ye...

Ze-Yuan Qiang, Ke Qin, Yuan-Xia Zhou et al. · 0 citations
Open access Jul 2026

Insulin gene-modified 3D stem cells for enhanced islet regeneration and systemic reversal of type 1 diabetes

A mechanically guided 3D stem cell–gene therapy platform with both endocrine and immunometabolic benefits in T1D is established, establishing a mechanically guided 3D stem cell–gene therapy platform with both endocrine and immunometabolic benefits in T1D.

Qian Li, Xiao Ma, Kefei Yuan et al. · 0 citations

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