An Extrapolation Physiologically Based Pharmacokinetic Model for Doxycycline to Predict Withdrawal Times in Yellow Catfish (Pelteobagrus fulvidraco) and Crayfish (Procambarus clarkii).
The aim of this study was to establish an extrapolation physiologically based pharmacokinetic (PBPK) model of doxycycline (DC) to predict its withdrawal times (WTs) in yellow catfish (Pelteobagrus fulvidraco) and crayfish (Procambarus clarkii). The body weight, organ volumes, hematocrit, and plasma protein binding rati...