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Author

Yong-Jun Chen

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Sep 2026

Hematopoietic HCAR2 attenuates atherosclerosis by enhancing efferocytosis via AMPK/ABCA1 signaling.

BACKGROUND Atherosclerotic plaque progression involves lipid accumulation, inflammation, and impaired efferocytosis, the macrophage mediated clearance of apoptotic cells. HCAR2, a metabolite sensing receptor highly expressed on macrophages, modulates immune metabolic responses, but its role in efferocytosis and atheros...

Jia-Cheng Chen, Li Jiang, Feng-Ying Zhang et al. · 0 citations
Review Open access Aug 2026

Integrating rare and common variation in epilepsy genetics: from genetic architecture to penetrance and clinical expressivity

Evidence across epilepsy subtypes is reviewed, focusing on convergence and divergence across the allelic spectrum, and how polygenic background and other modifiers may influence penetrance and clinical expressivity among carriers of rare pathogenic variants and CNVs is discussed.

Ming-Shan Cai, Hou-Rui Li, Peng Liao et al. · 0 citations

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