Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline
Purpose Aging is associated with a progressive decline in skeletal muscle function and motor coordination, contributing to reduced mobility and quality of life. While exercise is a well-established intervention to counteract age-related deterioration, the underlying molecular mechanisms in both muscle and the brain rem...