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Yoshinari Obata

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Open access Oct 2026

ALIX-dependent small extracellular vesicles from tissue-resident mesenchymal cells regulate pancreatic β cell proliferation in obesity

Cells throughout the body release small extracellular vesicles (sEVs), including exosomes, that function as modulators of both local and systemic metabolism. Using mice in which ALIX, a key regulator of sEV biogenesis, was selectively deleted in PDGFRα+ mesenchymal progenitors (Pα-ALIXKO mice), we demonstrate a critica...

Y. Uehara, Hirofumi Nagao, Aoki Tobimatsu et al. · 0 citations

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