Open access
Sep 2026
Detection of α-synuclein seeding activity in tear fluid as a candidate biomarker for Parkinson's disease
Background Parkinson's disease (PD) is an α-synucleinopathy, and pathological α-synuclein (α-Syn) is detectable in peripheral tissues and fluids. However, the diagnostic utility of tear fluid as a minimally invasive source for α-Syn seed detection remains unclear. We aimed to detect α-Syn seeds in tear fluid and evalua...
Asako Kakimoto, K. Satoh, Tomoko Tsukahara-Kawamura et al.
· Journal of Parkinson's Disea... · 0 citations