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Open access Feb 2026

Social determinants of health and risk of dementia in people with and without type 2 diabetes - findings from two large national-scale cohorts.

INTRODUCTION Explore association between a weighted social determinants of health (SDOH) score and incident dementia in adults with and without type 2 diabetes (T2D). METHODS Among 10,071 UK Biobank adults with T2D and 11,780 euglycemic individuals, SDOH indicators were weighted using elastic net and categorized as f...

You Lu, Y. Yoshida · 0 citations
Open access Aug 2026

The Joint Effects of Life's Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us.

OBJECTIVE We examined how cardiovascular health (CVH), measured by Life's Essential 8 (LE8), and genetic risk are jointly associated with risks of mild cognitive impairment (MCI), dementia, and related cognitive outcomes in people with diabetes. RESEARCH DESIGN AND METHODS We analyzed 41,374 participants without deme...

Xiu Wu, Y. Zu, You Lu et al. · 0 citations

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