You-Qiong Ye

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targeted agents (bevacizumab for cohort B an...

Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

ABSTRACT Spatial transcriptomics (ST) analysis is often hindered by technical limitations and methodological biases that let dominant signals overshadow subtle but crucial biological patterns, such as rare cell types and fine‐grained heterogeneity. This is especially true for high‐complexity datasets from platforms lik...

Mesenchymal Tumors Feature a Spatially Defined Glial-Tip Cell Niche Around the Tumor Boundary in Microsatellite-Stable Colorectal Cancer.

Colorectal cancers (CRC) with microsatellite stability (MSS) and instability (MSI) differ in tumor microenvironment (TME) composition and clinical treatment and outcomes. While MSI CRC is considered to be sensitive to immune checkpoint blockade therapy, MSS tumors are largely resistant. Characterizing the spatial TME d...