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Molecular docking results provided a molecular basis for the conjugate's interaction with target proteins (PDB IDs: 4LFU and 4TQX), suggesting its potential as a quorum-sensing modulator.
In vivo experiments reveal that the hydrogel significantly accelerated wound closure via improved re-epithelialization, collagen production, and neovascularization and modulated macrophage polarization toward M2 phenotype in full-thickness wound model in streptozotocin (STZ)-induced diabetic mice, suggesting this photocrosslinked hydrogel system can serve as a promising wound dressing for hard-to-heal chronic wounds.