Author

Young Nyun Park

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Review Open access Sep 2026

Integration of histopathology and molecular features for the classification of benign and malignant hepatocellular neoplasms.

The diagnostic of hepatocellular adenoma (HCA) and hepatocellular carcinoma (HCC) has shifted from a classical morphological evaluation to a complex and precise morpho-molecular analysis that represents a core focus of the updated 6th edition of the WHO classification of digestive system tumours. Four molecular pathway...

Christine Sempoux, Young Nyun Park · Virchows Archiv · 0 citations

Open access Sep 2026

A refined MASH–HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression

Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabolically relevant, time-efficient MASH-to-HCC mode...

Hyunmi Kim, Gye-Hyeong Kim, H. Yeon et al. · Experimental and Molecular M... · 0 citations

Open access Sep 2026

Dysregulated m6A via compensatory arginine methylation primes premalignancy in metabolic dysfunction–associated steatotic liver disease

Hepatocellular carcinoma (HCC) originates from premalignant disease-associated hepatocytes (daHeps) that emerge during the progression of metabolic dysfunction–associated steatotic liver disease (MASLD) to metabolic dysfunction–associated steatohepatitis (MASH). As daHeps are compensatorily primed by metabolic stress,...

Geun-Woo D. Kim, Dahee Choi, Soo-Young Kim et al. · Science Advances · 0 citations