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Author

Youngsuk Seo

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Review Open access Aug 2026

Beyond the sugar coating: mucin-type O-Glycosylation as an underappreciated player in brain function and disease.

This perspective synthesizes recent advances to highlight the potential importance of a "brain O-glycan code" in brain health and disease, and discusses how remodeling of this glycan landscape may intersect with aging, neuroinflammation, and synaptic plasticity.

Youngsuk Seo, Hyun Joo An, Boyoung Lee · 0 citations
Open access Aug 2026

Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation

The TAM receptor AXL is identified as a molecular transducer that couples Aβ sensing to the regulation of autophagy and neuroinflammation in astrocytes and proposed the AXL-ICD/SIRT2 axis as an effective therapeutic target to reduce Aβ burden and neuroinflammation in AD.

T. Kim, Mridula Bhalla, Uiyeol Park et al. · 0 citations

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