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Author

Youngsun Lee

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Open access Jul 2026

Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability

These findings identify a primate-specific cascade linking Alu-mediated genomic rearrangements to zinc dyshomeostasis and Golgi pathology and suggest that dysregulation of the ZnT6–Golgi axis may represent a vulnerability and therapeutic target in structural variant–driven neurodegeneration and possibly in a subset of sporadic cases.

Youngsun Lee, Onju Ham, Hana Lee et al. · 0 citations