Cabazitaxel and camptothecin co-loaded in pH-sensitive transferrin-targeted, PEGylated cholesterol-based poly(amidoamine) dendrimers as a synergistic combination for prostate cancer.
Encapsulation of the CBZ/CPT combination using optimized synergistic ratio within transferrin-functionalized, PEGylated cholesterol-based poly(amidoamine) dendrimers significantly potentiated the antiproliferative activity of CBZ by 3.93, 4.72, and 5.06-fold in these three cell lines, respectively.